The 2020–21 Cayman Islands Premier League season was the 42nd edition of top tier Cayman Islands Premier League football competition in the Cayman Islands.
The season began on 25 September 2020 and concluded on 28 February 2021.
[2] Bodden Town were the defending champions from the previous season.
Following the previous season, two teams, Alliance FC and North Side SC were relegated to the First Division, reducing the number of teams in the league to ten.
This article about a CONCACAF/North, Central American and Caribbean association football competition is a stub.