The game-week two match between Bourg-Péronnas and Annecy was postponed due to the visiting team having confirmed cases of COVID-19.
[15] Laval's trip to SC Bastia in game-week 9 was postponed due to the squad isolating after a positive diagnosis.
[18] Game-week 11 saw the postponements of Annecy v SC Lyon, Quevilly-Rouen v Stade Briochin and Villefranche v Sète due to Covid cases.
[19][20][21] Four matches were rearranged for the catch-up week of 28 to 30 October; Quevilly-Rouen v Bourg-Péronnas, Sète v Red Star, Annecy v Villefranche, and SC Lyon v Cholet, but postponed for a second time due to Covid cases.
[34] Positive cases at Créteil caused the postponement of their matches with Boulogne (27 March) and Le Mans (2 April).
[41] Due to the 2020–21 Championnat National 2 season being declared void, the normal relegation rules did not fully apply, as there was no balancing promotion from that division.
However, the regulations of the Championnat National state that the team classified in last position is relegated without the possibility of repechage.