The 2020–21 College of Charleston Cougars men's basketball team represented the College of Charleston in the 2020–21 NCAA Division I men's basketball season.

The Cougars, led by seventh-year head coach Earl Grant, play their home games at the TD Arena in Charleston, South Carolina as members of the Colonial Athletic Association.

In a season limited due to the ongoing COVID-19 pandemic, the Cougars finished the season 9–10, 6–4 CAA play to finish in third place.

They lost in the quarterfinals of the CAA tournament to Drexel.

They lost in the quarterfinals of the CAA tournament to Delaware.