The 2020–21 Clemson Tigers men's basketball team represented Clemson University during the 2020–21 NCAA Division I men's basketball season.

The Tigers were led by eleventh-year head coach Brad Brownell and played their home games at Littlejohn Coliseum in Clemson, South Carolina as members of the Atlantic Coast Conference.

As the fifth seed in the ACC tournament they earned a bye into the Second Round where they lost to Miami.

They earned an at-large bid to the NCAA tournament as a seven seed in the Midwest Region.

[1] The NCAA tournament and NIT were also cancelled due to the pandemic.