In addition to the domestic league, Club Brugge participated in this season's editions of the Belgian Cup, the Belgian Super Cup, the UEFA Champions League, and the UEFA Europa League.

The season covered the period from 1 July 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Jupiler Pro League The group stage draw was held on 1 October 2020.

The draw for the round of 32 was held on 14 December 2020.