On December 20, 2020, the league temporarily realigned into four divisions with no conferences due to the COVID-19 pandemic and the ongoing closure of the Canada–United States border.
As a result of this realignment, the Avalanche played this season in the West Division and only played against the other teams in their new division during the regular season and the first two rounds of the playoffs.
On April 22, the Avalanche clinched a playoff berth following a 4–2 win over the St. Louis Blues.
[2] They clinched their third Presidents' Trophy, as well as their tenth division championship, with a 5–1 victory over the Los Angeles Kings in their last game of the season on May 13.
[3] The Avalanche swept the St. Louis Blues in the First Round, with a 5–2 win in game four.