The Bluejays were led by 11th-year head coach Greg McDermott and played their home games at the CHI Health Center Omaha in Omaha, Nebraska, as members of the Big East Conference.

They defeated Butler and UConn in the Big East tournament before losing to Georgetown in the championship game.

They defeated UC Santa Barbara[1] and Ohio to advance to the Sweet Sixteen.

[4][5] On March 4, 2021, head coach McDermott was suspended for using racially insensitive language to his team.

[6] On March 8, the school reinstated McDermott after only missing one game and allowing him to coach in the Big East and NCAA Tournaments.