The 2020–21 Deportivo Cruz Azul season was the 94th season in the football club's history and the 56th consecutive season in the top flight of Mexican football.

Cruz Azul competed in Liga MX and the CONCACAF Champions League.

|} Win Draw Loss Fixtures Last updated: 16 September 2021 Source: Mediotiempo.com

Includes all competitive matches.

Sources: Soccerway, Liga MX, CONCACAF Champions League