The 2020–21 Cupa României was the 83rd season of the annual Romanian primary football knockout tournament.

Times up to 26 October 2020 and from 29 March 2021 are EEST (UTC+3).

Times between 27 October 2020 and 28 March 2021 are EET (UTC+2).

The following 128 teams qualified for the competition: Source:[1] The first rounds, and any preliminaries, are organised by the Regional Leagues.

The semi-final matches are played in a two-legged system.