The 2020–21 DePaul Blue Demons women's basketball team represented DePaul University during the 2020–21 NCAA Division I women's basketball season.

The Blue Demons were led by thirty-fifth year head coach Doug Bruno and played their home games at the Wintrust Arena as members of the Big East Conference.

[1][2] As the fourth seed in the Big East tournament they lost in the Quarterfinals to Villanova.

The received an at-large invitation to the WNIT, where they played in the Rockford Regional.

DePaul won the Big East Conference tournament championship game over Marquette, 88–74.