The Blue Devils played their home games at Cameron Indoor Stadium in Durham, North Carolina, as a member of the Atlantic Coast Conference.

Known for consistent high-level performance under Krzyzewski's tenure, the Blue Devils struggled to match their norm this season.

Duke fell out of the AP and Coaches Poll rankings within the first few weeks and struggled to maintain a winning record.

[18] Source[25] On January 18, 2021, Duke fell out of the AP Top 25 ranking for the first time since February 8, 2016.

This marked the first time since December 25, 1961 that Duke, Kentucky and North Carolina were all out of the Top 25 ranking.