The 2020–21 Duquesne Dukes men's basketball team represented Duquesne University during the 2020–21 NCAA Division I men's basketball season.

The team was led by fourth-year head coach Keith Dambrot, and played its home games at the UPMC Cooper Fieldhouse in Pittsburgh, Pennsylvania and Kerr Fitness Center in McCandless, Pennsylvania as a member of the Atlantic 10 Conference.

The team defeated Richmond during the second round of the A-10 tournament, before losing in the quarterfinals to St. Bonaventure.

6 seed in the A-10 tournament, it was scheduled to face No.

14 Fordham in the second round, but the tournament was canceled due to the COVID-19 pandemic.