[4] After mixed results in pre-season friendlies, Dynamo saw a strong start to their season with wins against first round DFB-Pokal opponent Hamburger SV, a 2.

Results improved after a 2–1 home victory over TSV 1860 Munich in round 10, however, with Dynamo going on an eight-game-long lossless streak.

Having now spent much of the season as the league's comfortable leader, things took a sudden turn for the worse when, in late March and April 2021, Dynamo lost three out of four league games in a row, culminating in a 0–3 home loss against Hallescher FC, at the time a team located firmly in the second half of the table.

Following the loss against Halle and a sudden drop from the league's top position, head coach Markus Kauczinski was sacked and replaced by Alexander Schmidt on 25 April.

Schmidt was able to reverse the team's fortunes immediately, winning five of the remaining six games without conceding a single goal, thus regaining the top position soon after his installation.