The 2020–21 Eastern Illinois Panthers men's basketball team represented Eastern Illinois University in the 2020–21 NCAA Division I men's basketball season.

The Panthers, led by ninth-year head coach Jay Spoonhour, played their home games at Lantz Arena in Charleston, Illinois as members of the Ohio Valley Conference (OVC).

On March 4, 2021, the school announced that they would not renew head coach Jay Spoonhour's contract.

[1] Nearly a month later, the school named Clemson assistant and former Evansville head coach Marty Simmons the team's new head coach.

They defeated Jacksonville State in the first round of the OVC tournament,[3] before losing in the quarterfinals to Austin Peay.