In addition to the domestic league, Empoli participated in this season's edition of the Coppa Italia.

The season covered the period from 5 August 2020 to 30 June 2021.

The team achieved a remarkable feat by finishing the season unbeaten at home.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.