Come the beginning of May, Burgener said he would sell his shares to a letterbox company called Basel Dream and Vision AG.

At the AGM the Bernhard Burgener as club chairman, Peter von Büren as finance director, and Streller stood down and vacated their positions.

[8] Youth coach Alex Frei had previously been trainer of the U-18 team and moved up to the U-21, but due to differences with the club directors he quit his job on 24 August.

[10] On 6 April 2021 the club announced that, due to the lack of sporting success, FC Basel 1893 were separating themselves from head coach Ciriaco Sforza with immediate effect.

[11] Until the end of the season, the first team would be looked after by the other previous assistant Patrick Rahmen, on an interim basis, as head coach.

Edon Zhegrova, Emil Bergström and Eric Ramires[15] also left the club and this because their loan periods had ended.

[16] After the season had started and the club failed to qualify for the group stage of the 2020–21 UEFA Europa League, the club made three announcements on 5 October, first that Blás Riveros had transferred to Brøndby,[17] then that Kemal Ademi had moved on to Fenerbahçe[18] and finally that Omar Alderete had been transferred to Hertha BSC.

[19] In the other direction, the players Konstantinos Dimitriou, Julian Von Moos, Aldo Kalulu and Dimitri Oberlin were back in the Basel squad after being out on loan for the previous season.

[23] Further, on 8 August the former Austria national team goalkeeper Heinz Lindner was signed in from Wehen Wiesbaden, with a three-year contract dated up until summer 2023.

[24] Then on 11 September Italian full-back Andrea Padula was signed in from FC Wil, where he had played the last half year under manager Ciriaco Sforza, also on a three-year contract.

[28] On 7 October the club then announced that Swiss international player Timm Klose had been signed in on loan from Norwich City.

Klose had played for the club as youth international, but had moved onto FC Thun in the 2011–12 Swiss Super League season to start his professional football career.

[29] Finally, only hours before the transfer-period closed, the club announced that Pajtim Kasami had signed in on a two-year contract.

On the 5 December 2020 Basel announced that they had terminated the contract with Dimitri Oberlin, without stating the reason, but according to the media it had something to do with a non-corona-conform party.

[32] On 14 January the club then announced that they had loaned Tician Tushi out to FC Wil until the end of the season, so that he could gain more playing experience.

On 11 May 2021 the FC Basel Holding AG chairman Bernhard Burgener and board member David Degen announced a transfer of ownership rights after months of massiv fan protests.

The new owner David Degen announced his intention of making Patrick Rahmen the head coach for the coming season in recognition of his good work with the first team.

[40] Furthermore, Degen announced a complete restructuring of the shareholding structures and a new board, which includes former FC Basel manager Christian Gross.

FCB started into the new season on Sunday 20 September with the home game against newly promoted FC Vaduz in St. Jakob-Park.

Sion, in the last game of the season, managed to climb from last position to second last and thus saved themselves from direct relegation and advanced to the promotion/relegation play-off.

However, Vaduz slipped to bottom position and were relegated to next season's Challenge League, which is the second tier of Swiss football.

Due to pitch conditions in the Stadion Schützenwiese in Winterthur the venue and date were changed and the match took place in the St. Jakob-Park on 17 February 2021 and it resulted in a debacle.

Directly after the break FCW forwards played as they wished with the FCB defence and added three more goals within 10 minutes.

Samir Ramizi twice, Roman Buess, Roberto Alves and Gezim Pepsi had scored to put FCW well in front before FCB could send out a small sign of life in the closing stages, with goals from Pajtim Kasami and Gonçalo Cardoso.

With the end score at 2–6 this also meant that this became the highest number of goals that the team had conceded in their home stadium since it was opened on 15 March 2001.

The match against Osijek was played on 17 September in their home stadium Stadion Gradski vrt and Basel won the game with 2–1.

[43] In the third qualifying round, to be played one week later on 24 September at home in the St. Jakob-Park and Basel were drawn against Anorthosis Famagusta.

Despite taking the lead after 54 minutes through a Penalty spot goal from Arthur Cabral, Basel's performance got worse and CSKA were able to get into the game.

It also includes players that were in the squad the day the season started on 19 September 2020, but subsequently left the club after that date.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.