In addition to the domestic league, Lokomotiv Moscow participated in this season's editions of the Russian Cup, the Russian Super Cup, and participated in the UEFA Champions League.

The season covered the period from 7 August 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Premier Liga The group stage draw was held on 1 October 2020.