On 11 August, it was announced that Shakhtar Donetsk would play their home games for the up-coming season at the NSC Olimpiyskiy in Kyiv.

[2] On 13 December 2020, Shakhtar's game against Inhulets Petrove scheduled for later in the day was called off due to the poor condition of the pitch in Kropyvnytskyi.

[4] On 1 February, Shakhtar Donetsk confirmed that Viktor Kovalenko had left the club to sign for Atalanta.

[6] On 12 May, three days after the end of the season, Shakhtar Donetsk announced that manager Luís Castro would be leaving the club after two-years in charge.

[7] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.