The 2020–21 Florida A&M Rattlers basketball team represented Florida A&M University in the 2020–21 NCAA Division I men's basketball season.

The Rattlers, led by fourth-year head coach Robert McCullum, played their home games at the Al Lawson Center in Tallahassee, Florida as members of the Mid-Eastern Athletic Conference.

They lost to Morgan State in the quarterfinals of the MEAC tournament.

The season marked the final season for Florida A&M as members of the MEAC as they rejoined the Southwestern Athletic Conference in 2021.

Florida A&M was ineligible for postseason play due to improper certification of student-athletes.