Instead of qualifying for the 2021–22 UEFA Europa League, teams placed 2nd, 3rd and the 2021 Rock Cup winners will qualify for the inaugural UEFA Europa Conference League.

The league paused after the game on 20 December between Bruno's Magpies and St Joseph's, but resumed on 22 February 2021 with Lions Gibraltar defeating College 1975 3-2.

Note: Flags indicate national team as has been defined under FIFA eligibility rules.

The season suffered early controversy when several teams were forced to forfeit games for violations of the Home Grown Player rule, due to confusion over the new rules regarding time limits for changes if a Home Grown Player is sent off.

Additionally, Boca Gibraltar failed to field a team on 5 December 2020 against Mons Calpe, subsequently forfeiting the tie.