The Cyclones were led by Steve Prohm, who coached his sixth and final season at Iowa State.

[1] They played their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference.

Following the end of the season, ISU athletic director Jamie Pollard announced that the school and Prohm had parted ways.

They were one of the few major conference teams in the country to complete a full season before play was halted nationally due to the COVID-19 pandemic.

[11] It was later announced on June 9 that Iowa State would face Oregon in the semifinal round of the Emerald Coast Classic.