The Jayhawks, members of the Big 12 Conference, played their home games at Allen Fieldhouse in Lawrence, Kansas.

In total they lost five of seven games, which lead to them unranked being in the AP poll released on February 8, 2021, ending their ranked streak at 231.

The loss was also the Jayhawks lowest points scored in the NCAA Tournament since the shot clock was introduced in the 1985–86 season.

Roster Last update: March 22, 2021 Due to COVID-19, KU's annual Late Night in the Phog, the Jayhawks name for their Midnight Madness event, was done virtually.

On October 13, Kansas and Missouri announced their scheduled renewal of their rivalry would be postponed a year and will begin play in 2021.

While it was not confirmed that they had tested positive, earlier that week Tristin Enaruna and David McCormack and been put in the COVID protocol after being exposed to it.