Due to COVID-19 pandemic, all the matches in the seventh season of ISL were played behind closed doors in three venues at Goa.

On 15 March 2020, Kerala Blasters appointed Karolis Skinkys as their new Sporting director ahead of the new season.

[10] On 5 August, Kerala Blasters completed the signing of left back Denechandra Meitei from TRAU F.C.

[17] On 9 September, the club announced the signing of India National Under 20 goalkeeper Prabhsukhan Singh Gill on a two-year deal.

[18] On 12 September, Kerala Blasters announced the contract extension of local boy Prasanth Karuthadathkuni until 2021.

[19] On 16 September, the club announced the signing of young midfielder Puitea from NorthEast United FC on a three-year deal.

[21] On 23 September, Blasters announced the signing of Spanish Midfielder Vicente Gómez Umpiérrez on a three-year deal.

[24] On 8 October, the Blasters started their pre-season training camp under the assistant coach Ishfaq Ahmed.

[28] On 7 November, the Blasters announced its association with BYJU'S, the world's largest Ed-Tech company, as their new title sponsor with an option to extend the sponsorship.

[34] On 8 December, the Blasters confirmed that the club captain Sergio Cidoncha, who tore his right ankle ligament during the match against Chennaiyin has left for Spain to recover from the injury and will miss the remainder of the season.

[39] On 28 December, the Blasters announced the signing of Juande as an injury replacement of Cido for the remainder of the season.

[49] On 29 January, the Blasters confirmed that Facundo Pereyra has suffered a broken nose before the match against Jamshedpur FC.

[54] On 17 February, the club parted ways with their head coach Kibu Vicuna on mutual consent.

[61] Ishfaq Ahmed (interim) (2 games) Win Draw Loss Cancelled Owing the COVID-19 pandemic, all the clubs including Kerala Blasters FC couldn't have a proper preseason.

The Blasters began their preseason against one of their fellow Indian Super League opponent, Hyderabad FC on 25 October 2020.