The 2020–21 LSU Lady Tigers basketball team represented Louisiana State University during the 2020–21 NCAA Division I women's basketball season.

The Lady Tigers, led by tenth-year head coach Nikki Fargas, played their home games at Pete Maravich Assembly Center and competed as members of the Southeastern Conference (SEC).

Fargas (nee Caldwell), an All-American player for the Tennessee Lady Vols from 1990-94 under Naismith Hall of Fame coach Pat Summitt, resigned following the season and became president of the WNBA's Las Vegas Aces.

LSU hired Baylor coach Kim Mulkey, a Louisiana native, as Fargas' successor on April 26, 2021.

[1] The Lady Tigers had one player selected to the preseason all-SEC teams.