The 2020–21 Lafayette Leopards men's basketball team represented Lafayette College in the 2020–21 NCAA Division I men's basketball season.

The Leopards, led by 26th-year head coach Fran O'Hanlon, play their home games at the Kirby Sports Center in Easton, Pennsylvania as members of the Patriot League.

With the creation of mini-divisions to cut down on travel due to the COVID-19 pandemic, they play in the Central Division.

[1] The Leopards finished the 2019–20 season 19–12, 10–8 in Patriot League play to finish in a tie for fourth place.

They defeated Army in the quarterfinals of the Patriot League tournament,[2] before losing in the semifinals to Colgate.