It started on 19 September 2020 with the first round of the regular season and ended on 6 May 2021 with the finals.
Consequently, there were not relegations to Liga Femenina 2 and the league was expanded to 16 teams for this season.
[1] A total of 16 teams consisted the league, including the same 14 sides from the 2019–20 season and two promoted from the 2019–20 Liga Femenina 2.
In order to preserve chronological evolvements, any postponed matches are not included in the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.
Source: FEB All official awards of the 2020–21 Liga Femenina de Baloncesto.