The 2020–21 Liga Primera de Nicaragua season was divided into two tournaments, Apertura and Clausura.

The regular stage and quadrangular winners played to decide the tournament's champion, but ultimately the same team won both and the final was not necessary.

The same format was recently adopted by the Costa Rican Primera División, but for both half seasons.

UNAN Managua finished last in the aggregate table and were relegated to the Segunda División.

The champions from the Segunda División, Deportivo Las Sabanas, were promoted in their place.