Vardar were the defending champions, having won their eleventh title in 2019–20 after was season abandoned due to the COVID-19 pandemic.
The first 22 matchdays will consist of a regular double round-robin schedule.
The league standings at this point will then be used to determine the games for the last 11 matchdays.
The table lists the positions of teams after each week of matches.
In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.