Floriana were the defending champions, having won their 26th title the previous season.
On 10 March 2021, due to the outbreak of the COVID-19 pandemic in Malta, a decision was made by the Government of Malta to suspend all football activities in Malta for one month.
[2] On 9 April, the season was abandoned due to the COVID-19 pandemic in Malta.
[3] Hamrun Spartans, who were top of the table at the time of the season's suspension, were declared the champions.
The promoted teams are Żejtun Corinthians, who will be playing their first season in the top division, and Lija Athetlic.