In March 2021, it was announced the team would make their Old Trafford debut in a league match against West Ham United despite fans not yet allowed to return to stadiums due to the ongoing COVID-19 pandemic.

[2] On 12 May 2021, it was announced Casey Stoney would be stepping down as manager at the end of the season amid tensions surrounding the lack of backing and resources from the club, particularly training facilities.

[9] Having progressed to the fifth round with a 6–0 win over Burnley, United were eliminated by 2020–21 Championship winners Leicester City 3–2 on 16 May 2021, Casey Stoney's last game in charge of the team.

[11] After losing the opening round fixture to Liverpool, United's second game against Everton was postponed due to safety concerns following overnight wind damage to the stadium.

Despite earning the bonus point, failing to win meant United could not progress to the knockout stage of the League Cup for the first time having reached the semi-finals the previous two seasons.