Teams that finished higher on the league in the previous season played their ties away.

[6][7][8][9][5] The 14 winners from the previous round joined the 2 Divizia Națională sides seeded 9-10, Florești and Dacia Buiucani.

The pairs for 2 Divizia Națională sides were determined in a draw held on 18 August 2020.

[11][12][13][5] The 8 winners from the previous round joined the remaining 8 Divizia Națională sides seeded 1-8.

The "home" team (for administrative purposes) was determined by an additional draw held on 6 May 2021.