The season ran from August 2020 to May 2021.
A total of 10 teams participate in this edition of the Second League.
The new members are Grbalj and Kom, who were relegated from 2019–20 Montenegrin First League, and winners of Montenegrin Third League playoffs - Berane and Igalo.
At the end of the season, the winner is automatically promoted to Montenegrin First League, while 2nd and 3rd placed teams play promotion play-offs, while 9th and 10th position lead to relegation to the Montenegrin Third League.
The 3rd-placed team (against the 10th-placed team of the First League) and the runners-up (against the 11th-placed team of the First League) will both compete in two-legged promotion play-offs after the end of the season.