The 2020–21 NWFL Premiership was the 31st season of Nigeria women's top-flight association football league and the first since its renaming.
[1] They were replaced by Dream Stars Ladies and Osun Babes who were initially relegated from the 2019 season.
On 25 April 2021, Rivers Angels won the Super Six tournament, clinching their 7th title and qualifying for the maiden CAF Women's Champions League.
[2] Subsequently, on 11 May, Ibom Angels and DreamStar Ladies were confirmed relegated, the later eliminated on goal difference.
The bottom four teams at the end of the regular season engaged each other in a round-robin playoff between 8 and 11 May to decide the last two clubs to be relegated.