On December 20, 2020, the league temporarily realigned into four divisions with no conferences due to the COVID-19 pandemic and the ongoing closure of the Canada–United States border.
As a result of this realignment, the Predators remained in the Central Division this season and would only play games against the other teams in their realigned division during the regular season and potentially the first two rounds of the playoffs.
On May 8, 2021, the Predators clinched a playoff berth after a 3–1 win over the Carolina Hurricanes.
[3] They were eliminated from the playoffs in the first round with a 4–3 overtime loss to the Carolina Hurricanes in game six.
The regular season schedule was published on December 23, 2020.