The 2020–21 season is New Basket Brindisi's 29th in existence and the club's 3rd consecutive season in the top tier Italian basketball.
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6+6 format (colours: Italian or homegrown players; foreign players; young players) Brindisi qualified to the 2021 Italian Basketball Cup by ending the first half of the LBA season in the 2nd position.
They played the quarterfinal against the 7th ranking Allianz Pallacanestro Trieste.