Another 11 were recommended for varying degrees of upgrade and repair works before they can be certified[4] This season saw a return of live NPFL matches.
On 1 August 2021, Akwa United won their first NPFL title after a convincing 5–2 home win over MFM with a game left.
Warri Wolves, Jigawa Golden Stars, Ifeanyiubah and Adamawa United were all confirmed relegated at the end of the campaign.
Nasarawa's Silas Nwankwo won the Eunisell golden boot award as the league topscorer for scoring lesser penalties having been tied with Akwa United's Charles Atshimene.
(H) – Home team Updated to match(es) played on 11 April 2021 The golden boot award was won by Nasarawa's Silas Nwankwo.