As the previous season was terminated due to the COVID-19 pandemic, with all results removed,[1] there were no changes in the allocations of teams for the Northern Premier League.
Due to the restrictions on clubs' ability to play matches in the COVID-19 lockdowns, competitions at Steps 3–6 were curtailed on 24 February 2021.
[4] The scheduled restructuring of non-league took place at the end of the season, with a new division added to the Northern Premier League at Step 4 for 2021–22.
Division One North West comprised 19 teams, one fewer than the previous season, following Droylsden's resignation from NPL.
Updated to matches played on November 4, 2020 Division One South East comprised the same set of 20 teams which competed in the aborted competition the previous season.