The season was affected by the COVID-19 pandemic and all Olympiacos' games were played behind closed doors.

Olympiacos participated in the Greek Super League winning their 46th title, finishing 26 points ahead of PAOK who came second.

Domestically the team participated in the Greek Football Cup as well.

Olympiacos qualified also for the UEFA Champions League group stage for a second consecutive season but failed to qualify to the knock-out phase.

Having finished third in their group, they were then transferred to UEFA Europa League knockout phase.