In addition to the domestic league, Paris Saint-Germain participated in this season's editions of the Coupe de France, the Trophée des Champions, and the UEFA Champions League.

Following the indefinite suspension of the Coupe de la Ligue, PSG did not compete in the tournament for the first time since 1995.

The season covered the period from 24 August 2020 to 30 June 2021.

The season was the first since 2012–13 without Edinson Cavani, who joined Manchester United, and the first since 2011–12 without Thiago Silva, who departed to Chelsea.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.