On December 20, 2020, the league temporarily realigned into four divisions with no conferences due to the COVID-19 pandemic and the ongoing closure of the Canada–United States border.
On April 29, 2021, the Flyers were eliminated from playoff contention following a 5–3 loss to the New Jersey Devils.
Among the team records set during the 2020–21 season was the Flyers giving up seven goals during the second period against the New York Rangers on March 17.
Below are the Philadelphia Flyers' selections at the 2020 NHL entry draft, which was originally scheduled for June 26–27, 2020 at the Bell Center in Montreal, Quebec, but was postponed on March 25, 2020, due to the COVID-19 pandemic.
It was held October 6–7, 2020 virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.