[2] Barcelona were the defending champions after the previous season ended after 21 games due to COVID-19 pandemic in Spain.
They retained their title emphatically, dropping only 3 points all season (a defeat by Atlético Madrid after already being declared champions), and also won the Copa de la Reina and UEFA Women's Champions League competitions.
[3] Eibar and Santa Teresa promoted from Segunda División Pro.
Tacón changed its name to Real Madrid after being absorbed by the namesake club.
In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.