The 2020–21 Primera División de El Salvador (also known as the Liga Pepsi) is the 22nd season and 43rd and 44th Primera División tournament, El Salvador's top football division, since its establishment of an Apertura and Clausura format.
and Once Deportivo de Ahuachapan are the defending champions of both Apertura and Clausura tournaments respectively.
Should the same team win both tournaments, both runners-up will qualify for CONCACAF League.
Should the final of both tournaments features the same two teams, the semifinalist with the better aggregate record will qualify for CONCACAF League.
El Vencedor announced that due to ongoing cost and lack of sponsorship, they would be ceding their spot to Atletico Marte.
Isidro Metapán Jocoro Limeño Once Deportivo Sonsonate Santa Tecla