The 2020–21 Prince Mohammad bin Salman League was the fourth season of the Prince Mohammad bin Salman League under its current name, and the 44th season of the Saudi First Division since its establishment in 1976.
They set the record for the earliest team to secure promotion with six games remaining as well as most points, most wins and most goals in a season.
[8] On 4 September 2020, Al-Hazem became the second club to be relegated, ending a 2-year stay in the Pro League following a 1–0 defeat away to Al-Shabab.
Al-Sahel and Arar will play in the Prince Mohammad bin Salman League for the first time in their history.
Al-Diriyah return to the MS League for the first time since getting relegated in 2015–16 season.
Al-Khaleej and Ohod will play in their 30th season in the MS League overtaking Al-Taawoun's record of 29 years in the second tier.