The 2020–21 Quaid-e-Azam Trophy was a first-class domestic cricket competition that took place in Karachi,[1] Pakistan, from 25 October 2020 to 5 January 2021.

[5][6] Central Punjab started their title defence poorly, with no wins from their first five matches.

[9] The final finished in a tie, with Central Punjab and Khyber Pakhtunkhwa sharing the title.

[14] On 21 October 2020, the Pakistan Cricket Board (PCB) confirmed the squads for the tournament.

[15] Ahead of the opening round of matches, Salman Butt withdrew from the tournament and was replaced by Ali Zaryab in Central Punjab's team.