The 2020–21 Radford Highlanders men's basketball team represented Radford University in the 2020–21 NCAA Division I men's basketball season.

The Highlanders, led by tenth-year head coach Mike Jones, played their home games at the Dedmon Center in Radford, Virginia, as members of the Big South Conference.

The Highlanders finished the 2019–20 season 21–11, 15–3 in Big South play, to win a share of the regular-season championship.

They defeated Charleston Southern in quarterfinals of the Big South tournament before losing in the semifinals to Hampton.

However, the NIT, and all other postseason tournaments, were cancelled amid the COVID-19 pandemic.