Qualifying for the 2021 NCAA National Collegiate Women's Ice Hockey Tournament, the program ranked as the #8 seed.

[2] During the first period of a January 30, 2021 tilt versus the Rochester Institute of Technology Tigers, team captain Lexi Templeman recorded the first natural hat trick of her career, part of a four-point offensive outburst in a 7-0 shutout win.

It marked the first natural hat trick scored by a Colonials skater since Michaela Boyle achieved the feat on November 24, 2019.

[3] On Senior Night, celebrated on February 20, 2021, goaltender Molly Singewald made her first career start.

[4] Making their fifth consecutive appearance in the CHA championship game, Gillian Thompson would score the game’s only goal, while Raygan Kirk recorded 36 saves in a tightly contested 1-0 victory on March 6 versus the Syracuse Orange, resulting in their third playoff crown.