[1] While the season originally started with a full round robin format, due to the pandemic the league switched to four groups of four teams, with the top two teams in each group qualifying to the champions round.
APR won the title on goal difference over AS Kigali as both teams finished with 19 points out of a possible 21, with both teams drawing each other 1–1 on the second match day.
[2] Five teams were at risk of the last relegation spot on the final day of the season.
[3] A total of 16 teams competed in the 2020–21 season with the top team qualifying for the CAF Champions League, the runner-ups qualifying for the CAF Confederation Cup and the bottom two relegated to the Rwandan Second Division.
Rutsiro and Gorilla FC were promoted to the league after making the second division play-off final.