A total of 21 teams contested the league, including eighteen sides from the 2019–20 season and three promoted from the 2019–20 TFF First League, including Hatayspor and BB Erzurumspor, as well as the winners of the 2019–20 TFF First League playoffs, Fatih Karagümrük.
Hatayspor made its debut in the Süper Lig.
Fatih Karagümrük returned following a 36 year hiatus after achieving two successive promotions.
The bottom four teams were relegated to the 2021–22 TFF First League.
4 Player scored four goals Rachid Ghezzal (Beşiktaş)