In addition to the domestic league, SPAL participated in this season's edition of the Coppa Italia.

The season covers the period from 3 August 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: Serie B The league fixtures were announced on 9 September 2020.