The 2020–21 San Francisco Dons men's basketball team represented the University of San Francisco during the 2020–21 NCAA Division I men's basketball season.

The Dons were led by head coach Todd Golden, his second year in the position.

They played their home games at the War Memorial Gymnasium as members of the West Coast Conference.

The Dons concluded the 2019–20 season 22–12, 9–7 in WCC play to finish in fifth place.

They lost in the quarterfinals of the WCC tournament to Pepperdine.